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目的：预测盐酸洛美沙星滴耳剂有效期，用以扩大洛美沙星的临床应用，增加耳科用药。方法：采用紫外分光光度法测定制剂含量，用经典恒温法和Ｗｅｉｂｕｌ概率法探讨其稳定性。结果：紫外分光光度法测定制剂含量平均回收率为９９．８０％，ＲＳＤ为０．６６％。经典恒温法预测本制剂在ｐＨ为５～６，２５℃贮存时有效期为５．１６年，Ｗｅｉｂｕｌ概率法预测其有效期为４．９８年。结论：紫外分光光度法测定盐酸洛美沙星滴耳剂快速简便，精密度好，可靠性高。在无阳光直射条件下室温贮存本制剂稳定性好。
OBJECTIVE: To predict the validity of Lomefloxacin Hydrochloride Eardrops to expand the clinical application of Lomefloxacin and to increase the use of otology. Methods: The content of the preparation was determined by ultraviolet spectrophotometry. The stability was discussed by classical thermostat method and Weibull probability method. Results: The average recovery of the product was 99.80% and the RSD was 0.66% by UV spectrophotometry. The classical thermostat method predicts that the preparation has a validity period of 5.16 years when stored at pH 5-6,25 ℃, and the Weibul Probability Method predicts its validity period is 4.98 years. Conclusion: UV spectrophotometry Lomefloxacin Hydrochloride Eardrops fast and easy, good precision, high reliability. In the absence of direct sunlight stored at room temperature the preparation of good stability.