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他汀药物除降脂作用外,还具有抗凝和抗血小板聚集、改善内皮功能、调节一氧化氮活性、稳定斑块以及抗炎等作用,即他汀药物的“多效性”。经皮冠状动脉介入治疗是冠状动脉粥样硬化性心脏病治疗中一个重要的治疗方法,但冠状动脉介入治疗过程中会导致血管壁损伤,激发血小板活性,导致微血栓形成,引起血管壁和微脉管系统末梢炎性反应等一系列不良反应。他汀药物的“多效性”可能会减少介入治疗导致的主要不良心血管事件的发生,达到改善冠状动脉粥样硬化性心脏病预后的目的。
In addition to lipid-lowering effect of statin drugs, but also has anticoagulant and anti-platelet aggregation, improve endothelial function, regulate nitric oxide activity, stabilize plaque and anti-inflammatory effect, that is, statin drugs “pleiotropic ”. Percutaneous coronary intervention is an important treatment for coronary atherosclerotic heart disease. However, during coronary intervention, vascular wall injury is induced and platelet activity is stimulated, resulting in the formation of micro-thrombus, causing the vessel wall and micro Vascular end of the inflammatory reaction and a series of adverse reactions. The “pleiotropic effect” of statin drugs may reduce the incidence of major adverse cardiovascular events resulting from interventional therapy and achieve the goal of improving the prognosis of coronary atherosclerotic heart disease.