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奥沙利铂是应用广泛的抗癌药物,但其神经毒性不容忽视。目前临床报道了许多奥沙利铂神经毒性的防治方法。其中“走走停停”的化疗策略在理论上有望从根源上预防奥沙利铂神经毒性的发生,但全面推广运用仍需时日。在药物防治方面,可通过抗氧化、螯合草酸盐、提高疼痛阈值、抗感觉过敏、营养神经等多种途径实现降低神经病变的发生率或减轻毒性程度,但至于何种途径最有效,目前并难以得出确切的结论。在中药防治方面,依据不同的经典理论和现代研究成果,目前有着多种不同治法治则的临床报道,但研究质量仍亟需提高。在针灸推拿防治方面,各医家取穴、刺法、补泻各有特色,有待进一步系统研究。
Oxaliplatin is a widely used anti-cancer drug, but its neurotoxicity can not be ignored. Currently many clinical reports of oxaliplatin neurotoxicity prevention and treatment methods. Which “stop and go ” chemotherapy strategy is expected in theory to prevent the occurrence of oxaliplatin neurotoxicity, but the full promotion of the use of time is still needed. In the aspect of drug prevention and treatment, the incidence of neuropathy can be reduced or the toxicity reduced through a variety of ways such as antioxidation, chelation of oxalate, enhancement of pain threshold, anti-hypersensitivity, nutrition nerves, etc. As to which route is most effective, At present, it is difficult to draw the exact conclusion. In the aspect of traditional Chinese medicine prevention and treatment, there are many clinical reports on the treatment of the rule of law based on different classic theories and modern research results, but the quality of the research is still in urgent need of improvement. In acupuncture and massage prevention and treatment, the doctors acupoints, acupuncture, reinforcing diarrhea each have their own characteristics, pending further systematic study.