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目的评价凝血因子替代性治疗在产科症候群导致DIC治疗中的作用。方法输新鲜冰冻血浆 (FFP) 80 0～ 3 0 0 0ml,平均(1 2 0 0± 1 4 2 )ml;输血 2 0 0～ 2 0 0 0ml,平均用 (40 0± 1 0 0 )ml;7例输血小板浓缩制品平均用 2单位 ,保证血小板计数 (Plt)大于 50× 1 0 9/L ,纤维蛋白原 (FIB)大于 2g/L。连续动态监测弥漫性血管内凝血 (DIC)指标的变化 ,评价替代治疗的效果。结果DIC全套检测指标均明显改善 (P <0 .0 5) ,除羊水栓塞 1例死亡外 ,其余均痊愈。DIC好转平均日数为 3天。结论积极替代治疗可明显改善产科症候群导致DIC的预后。
Objective To evaluate the role of alternative coagulation factor in the treatment of obstetrics and gynecology caused by DIC. Methods The fresh frozen plasma (FFP) was transfused from 80 0 to 300 ml (mean, 12 00 ± 1 4 2) ml, transfused from 200 ml to 20 000 ml, with an average of (40 0 ± 1 0 0) ml ; 7 cases of platelet concentrates with an average of 2 units, to ensure that the platelet count (Plt) greater than 50 × 109 / L, fibrinogen (FIB) greater than 2g / L. Continuous dynamic monitoring of diffuse intravascular coagulation (DIC) changes in indicators to evaluate the effect of alternative treatment. Results Complete set of DIC test indicators were significantly improved (P <0.05), except for amniotic fluid embolism in 1 case of death, the rest were cured. DIC improved the average number of days for 3 days. Conclusions Active replacement therapy can significantly improve the prognosis of obstetric syndrome.