p53基因是发现较早且研究较多的抑癌基因，大量研究表明，p53基因突变与多种肿瘤的发生与发展密切相关，其突变位点主要集中于第5~8外显子。本实验采用PCR－SSCP的方法对58例乳腺癌及8例良性乳腺肿瘤组织进行了p53基因第5~8外显子的突变分析，以期对p53基因突变与乳腺癌的相关? The p53 gene is an earlier and more frequently studied tumor suppressor gene. A large number of studies have shown that p53 gene mutation is closely related to the occurrence and development of various tumors, and its mutation sites are mainly concentrated in exon 5-8. In this study, PCR-SSCP was used to analyze mutations of exon 5-8 of p53 gene in 58 cases of breast cancer and 8 cases of benign breast tumors, in order to study the association between p53 gene mutation and breast cancer.