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目的探讨环境因素引起的非酒精性脂肪肝与胰岛素抵抗的关系,并观察吡格列酮对其的影响。方法应用59%高脂饮食喂养大鼠4周制成胰岛素抵抗的动物模型后,给予药物吡格列酮干预4周,观察非酒精性脂肪肝对大鼠胰岛素敏感性的影响以及吡格列酮对其的干预。结果经59%高脂饮食喂养8周后,模型对照组较正常对照组大鼠空腹血糖及胰岛素均明显增高,血脂、血清游离脂肪酸(FFA)亦明显增高。而给予吡格列酮干预后药物干预组较模型对照组大鼠空腹血糖及胰岛素均明显减低,血脂、血清FFA亦明显减低。结论高脂饮食可诱导非酒精性脂肪肝并导致胰岛素抵抗,而吡格列酮可干预此过程。
Objective To investigate the relationship between nonalcoholic fatty liver caused by environmental factors and insulin resistance and to observe the effect of pioglitazone on it. Methods The model of insulin resistance was induced by feeding a 59% high-fat diet for 4 weeks and then the animals were treated with pioglitazone for 4 weeks. The effects of nonalcoholic fatty liver on the insulin sensitivity were observed, and the effects of pioglitazone on it were also investigated. Results After fed with 59% high-fat diet for 8 weeks, the fasting blood glucose and insulin in the model control group were significantly higher than those in the normal control group, and the levels of serum lipids and free fatty acids (FFA) were also significantly increased. After administration of pioglitazone, the fasting blood glucose and insulin in the intervention group were significantly lower than those in the model control group, and the levels of serum lipids and serum FFA were also significantly decreased. Conclusion High-fat diet induces nonalcoholic fatty liver disease and leads to insulin resistance, while pioglitazone can interfere with this process.