关于利福布丁(Rifabutin,LM427)和利福平试管内抗菌活性及血浆和组织内药物浓度已有报道,但尚缺乏长效药物利福喷丁(Rifapentine,MDL427)及FCE22807组织内高浓度的研究。作者对上述4种药物在试管内的抗结核杆菌和田鼠分支杆菌活性及药物穿透小鼠腹腔巨噬细胞(PM)的能力进行了测定。试管实验时药物和细菌接触3天,用田鼠分支杆菌感染 In vitro antibacterial activity of Rifabutin (LM427) and rifampicin, and plasma and intra-tissue drug concentrations have been reported, but long-acting drugs such as Rifapentine (MDL427) and high concentrations of FCE22807 the study. The authors tested the activity of the above four drugs against Mycobacterium tuberculosis and Mycobacterium voles in vitro and their ability to penetrate mouse peritoneal macrophages (PMs). In vitro test drug and bacteria contact for 3 days, with Mycobacterium Microtophila infection