论文部分内容阅读
目的 :探讨胆囊结石、胆石伴梗阻性黄疸时 ET- 1、NO变化及其临床意义。方法 :前瞻性比较观测正常人、胆囊结石、胆石并黄疸病员血液 NO、ET- 1及肝功能指标。结果 :胆石并黄疸组 :NO、白蛋白、球蛋白、AL T、血清胆红素和另两组比较 ,有显著差别 (P<0 .0 5 ) ;NO与 ET- 1、AL T呈负相关 (γET=- 0 .6 17,P<0 .0 1;γAL T=- 0 .319,P<0 .0 5 )。胆囊结石组 :ET- 1和 NO均高于正常对照组 (P<0 .0 5 )。结论 :胆石病员NO高于正常对照组 ,提示 NO可能通过松弛胆囊平滑肌 ,在胆囊功能紊乱的发病机制中起一定作用。梗阻性黄疸时 NO/ ET- 1的原有平衡关系向 NO一侧倾斜将不利于止血 ,这可能是一些病员凝血因子并不缺乏 ,仍易发生止血困难的原困
Objective: To investigate the changes of ET-1 and NO in gallstone and gallstone with obstructive jaundice and its clinical significance. Methods: prospectively observe the blood NO, ET-1 and liver function indexes of normal, gallstone, gallstone and jaundice patients. Results: Compared with the other two groups, the levels of NO, albumin, globulin, ALT and serum bilirubin in gallstone and jaundice group were significantly different (P <0.05); NO, ET-1 and ALT were negative (ΓET = -0.617, P <0.01; γAL T = -0.319, P <0.05). Gallstone group: ET-1 and NO were higher than the normal control group (P <0.05). CONCLUSION: NO in gallstone patients is higher than that in normal controls, suggesting NO may play a role in the pathogenesis of gallbladder dysfunction by relaxing the gallbladder smooth muscle. Obstructive jaundice NO / ET-1 balance of the original balance to the NO side of the tilt will not conducive to stop bleeding, which may be some patients not lack of clotting factor is still prone to bleeding difficulties