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目的探讨影响2型糖尿病无视网膜病变(DM)进展为糖尿病性视网膜病变非增殖期(DR)过程中的相关因素。方法选择浙江中医药大学附属第一医院2012年11月至2013年5月收治的64例糖尿病患者,其中无视网膜病变2型糖尿病(DM)32例,非增殖期视网膜病变糖尿病32例。检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、高密度脂蛋白胆固醇(HDL-C)、脂联素(ADPN)、肝细胞生长因子(HGF)和尿微量白蛋白(mALB)的浓度变化,根据所得的结果进行组间比较。结果 DM组与DR组FPG浓度分别为(7.15±0.65)mmol/L、(7.0±0.45)mmol/L,二者差异无统计学意义。HBA1c(8.15±0.23)%vs(9.24±0.29)%、HDL-C(1.59±0.06)mmol/L vs(1.40±0.41)mmol/L、脂联素(1002.14±132.04)mg/L vs(941.44±118.51)mg/L和尿微量白蛋白(21.61±3.93)mg/L vs(209.15±98.15)mg/L的结果提示两组间差异有统计学意义(P<0.05)。肝细胞生长因子(21.61±3.93)ng/L vs(16.74±1.65)ng/L,在DM组与DR组间差异无统计学意义(P>0.05)。结论与DM患者相比,DR患者的高糖状态,HDL-C降低,ADPN下降以及早期肾脏损害程度较重,密切监测以上指标有利于判断早期DR发生。
Objective To investigate the factors affecting the progression of non-retinopathy (DM) in type 2 diabetes mellitus (DM) to non-proliferative phase (DR) in diabetic retinopathy. Methods Sixty-four diabetic patients admitted to the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from November 2012 to May 2013 were selected, including 32 cases of type 2 diabetes mellitus (DM) without retinopathy and 32 cases of non-proliferative diabetic retinopathy. The concentrations of fasting blood glucose (FPG), HbA1c, HDL-C, ADPN, HGF and mALB were measured. According to the results obtained for comparison between groups. Results The FPG concentrations in DM group and DR group were (7.15 ± 0.65) mmol / L and (7.0 ± 0.45) mmol / L, respectively. There was no significant difference between the two groups. HBA1c (8.15 ± 0.23)% vs 9.24 ± 0.29%, HDL-C 1.59 ± 0.06 mmol / L vs 1.40 ± 0.41 mmol / L, and adiponectin 1002.14 ± 132.04 mg / L vs 941.44 ± 118.51) mg / L and urine microalbumin (21.61 ± 3.93) mg / L vs (209.15 ± 98.15) mg / L, respectively. The difference between the two groups was statistically significant (P <0.05). Hepatocyte growth factor (21.61 ± 3.93) ng / L vs (16.74 ± 1.65) ng / L, there was no significant difference between DM group and DR group (P> 0.05). Conclusion Compared with DM patients, DR patients with high glucose status, HDL-C decreased, ADPN decreased and the degree of early renal damage is severe, close monitoring of these indicators will help determine the early DR occurred.