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神经退行性病变是一种可导致神经细胞渐进性退变或死亡的不可治愈性疾病。该疾病可诱发功能性运动障碍以及精神问题,比如痴呆。在诸多种类的神经退行性病变中,阿尔茨海默病占据最大比例。瞬时受体电位M2型(TRPM2)离子通道是一个可通过钙离子的非选择性阳离子通道。研究表明,TRPM2离子通道有可能通过不同路径(包括炎症路径)参与阿尔茨海默病的病理过程。本综述主要通过对TRPM2与Aβ、氧化应激以及钙离子之间关系的讨论,总结概括了TRPM2在阿尔茨海默病病理学中的作用,也对近期TRPM2药理学领域的研究进展进行了探讨,并对如何进一步研究TRPM2在阿尔茨海默病中的作用进行了展望。
Neurodegenerative diseases are an incurable disease that leads to progressive degeneration or death of nerve cells. The disease can elicit functional dyskinesias as well as mental problems such as dementia. Of the many types of neurodegenerative diseases, Alzheimer’s disease accounts for the largest proportion. Transient Receptor Potential The TRPM2 ion channel is a nonselective cation channel that passes calcium ions. Studies have shown that TRPM2 ion channels may participate in the pathological process of Alzheimer’s disease through different pathways, including inflammatory pathways. This review mainly summarizes the role of TRPM2 in the pathology of Alzheimer’s disease by discussing the relationship between TRPM2 and Aβ, oxidative stress and calcium ion, and also discusses the recent advances in the pharmacology of TRPM2 , And prospected how to further investigate the role of TRPM2 in Alzheimer’s disease.