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目的观察老年肺炎患者抗生素相关性腹泻(AAD)的综合干预效果。方法选取2014年1月—2015年3月江苏省南通市肿瘤医院诊治的老年肺炎患者180例,采用随机数字法将所有患者分为对照组和观察组,各90例。对照组患者给予经验性抗生素治疗;观察组患者在对照组治疗基础上采取规范抗生素应用、提高病原微生物送检率、预防性应用微生态制剂及减少引起AAD的危险因素等综合干预措施。结果观察组患者联合应用抗生素种类少于对照组,抗生素应用时间短于对照组,病原微生物送检率高于对照组,AAD发生率低于对照组(P<0.05)。结论综合干预可减少老年肺炎患者联合应用抗生素种类、缩短抗生素应用时间、提高病原微生物送检率、降低AAD发生率。
Objective To observe the comprehensive intervention effect of antibiotic-associated diarrhea (AAD) in elderly patients with pneumonia. Methods One hundred and eighty elderly patients with pneumonia were selected from January 2014 to March 2015 in Nantong Tumor Hospital of Jiangsu Province. All patients were divided into control group and observation group by random number method. The patients in the control group were treated with empirical antibiotics. The patients in the observation group took the standardized antibiotics to improve the delivery rate of the pathogenic microorganisms, prophylactic use of probiotics and reduce the risk factors of AAD. Results Compared with the control group, antibiotic application time was shorter in the observation group than in the control group. The detection rate of pathogenic microorganisms in the observation group was higher than that in the control group, and the incidence of AAD was lower than that in the control group (P <0.05). Conclusion Comprehensive intervention can reduce the combination of antibiotics in elderly patients with pneumonia, shorten the application time of antibiotics, improve the rate of pathogenic microorganisms and reduce the incidence of AAD.