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目的：观察复方阿嗪米特联合复合乳酸菌胶囊治疗腹泻型肠易激综合征（IBS）的临床疗效。方法将108例腹泻型IBS患者随机分为治疗组（A组，n=54）和对照组（B组，n=54）。A组给予复方阿嗪米特肠溶片联合复合乳酸菌胶囊口服。B组采用复合乳酸菌胶囊口服。2组均治疗4周后观察疗效。结果总有效率A组为87.0%，B组64.8%，差异有统计学意义（P＜0.05）。结论复方阿嗪米特联合复合乳酸菌胶囊治疗腹泻型IBS较单纯复合乳酸菌胶囊疗效更为显著，值得进一步研究和临床推广。“,”Objective To investigate the curative effect of compound azintamide enteric coated tablet combined with lactobacillus complex capsule for diarrhea-predominant pattern irritable bowel syndrome. Methods 108 patients with diarrhea-predominant pattern irritable bowel syndrome were randomized into treatment group (n=54, group A, treated with compound azintamide enteric coated tablet combined with lactobacillus complex capsule), and control group (n=54, group B, treated with lactobacillus complex capsule only). The two groups were treated for four weeks, and the curative effects were observed. Results The total effective rate were 87.0%in group A, and 64.8%in group B with significant difference (P<0.05). Conclusion The curative effect of compound azintamide enteric coated tablet combined with lactobacillus complex capsule was more significant than that of lactobacillus complex capsule used alone. It is worthy of further research and clinical promotion.