用ＰＥＧ粗提血清中的ＩｇＧ刺激鼠甲状腺细胞（ＦＲＴＬ─５）株，测定释入培养液中的ｃＡＭＰ含量表示ＴＳＡｂ活性。所测ＴＳＡｂ活性，正常组为１００．１±４８．８％（ｎ＝１８，±ｓ）；１７例未治甲亢病组为１４４２．８±１１９８．１％，全部（１００％）ＴＳＡｂ阳性；１６例甲亢病复发组为１１４５．７±１２１７．７％，其中１４例（８７．５％）ＴＳＡｂ阳性；１０例甲亢病缓解组为１２４．２±８２．５％，其中２例（２０％）ＴＳＡｂ阳性；３例桥本氏甲状腺炎中２例在正常范围内，１例反应性增高。ＴＳＡｂ活性测定可作为甲亢病诊断及预后判断的一项指标。 The rat thyrocytes (FRTL-5) were stimulated with IgG in serum and the amount of cAMP released into the culture medium was determined to indicate TSAb activity. The measured TSAb activity was 100.1 ± 48.8% (n = 18, ± s) in the normal group and 1442.8 ± 1198.1% in 17 unrelated hyperthyroidism patients, all of which (100%) were positive for TSAb. TSAb was positive in 14 cases (87.5%) in 16 cases of hyperthyroidism recurrence group, and 124.2 ± 82.5% in 10 cases of hyperthyroidism remission group, of which 2 cases (20% ) TSAb positive; 3 cases of Hashimoto’s thyroiditis in 2 cases in the normal range, 1 case of reactivity increased. TSAb activity determination can be used as an indicator of diagnosis and prognosis of hyperthyroidism.