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目的：探讨急性颈髓损伤（ ACSCI ）患者继发水电解质紊乱的发病机制，并总结其治疗经验。方法回顾性分析2010年1月－2015年12月我院重症医学科收治的急性颈髓损伤患者67例的临床资料，对可能导致水电解质紊乱的相关因素进行统计学分析，并探讨其治疗方法。结果 ACSCI继发水电解质紊乱较常见，本组达83．58％（56／67），其中继发低钠血症的发生率为79．10％（53／67），其发生与脊髓损伤程度、损伤平面、是否合并感染及呼吸衰竭等有关。经适当补液及积极补充高浓度钠盐治疗后，低钠血症均较治疗前显著改善，但部分患者血钠浓度始终不能恢复正常。结论 ACSCI常可导致严重、顽固的低钠血症，其发生机制可能与脑盐耗综合征（ CSWS ）相似，适当补液、补充高浓度钠盐及多尿患者补充脑垂体后叶素治疗有效。“,”Objective To analysis the pathogenesis and treatment experience in patients with acute spinal cord injury ( ACSCI ) patients with secondary water and electrolyte disorders .Methods Retrospective analysis the 67 cases patients with acute spinal cord injury of critical care medicine in our hospital from January 2010-December 2015,analysis the relevant fac-tors that may lead to water and electrolyte disturbance ,and investigate the treatment .Results ACSCI secondary water and e-lectrolyte disorders was common ,amounted to 83.58%(56/67),where in the secondary hyponatremia was 79.10%(53/67). Its occurrence and degree of spinal cord injury ,damage to the plane ,whether infection and respiratory failure and so on .After proper rehydration and replenish positive high concentration salt treatment ,Hyponatremia significantly improved compared with before treatment ,However ,some patients with serum sodium concentration can never return to normal .Conclusion Proper re-hydration and high concentrations of salt added ,polyuria patients supplement posterior pituitary were efficacy .