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目的探讨内分泌治疗对晚期前列腺癌的临床疗效。方法对23例晚期前列腺癌患者采用内分泌治疗(去势及抗雄激素治疗),随访症状改善情况、肿瘤消退情况、定期复查PSA及肝功能,记录生存时间。结果23例治疗后,第1年,21例患者PSA降至正常。第2年,19例病情稳定,4例病情恶化死亡。第3年,12例患者生存,累计11例死亡。结论晚期前列腺癌患者,治疗初PSA很快降至正常者疗效肯定,PSA降低慢,且不能下降至正常或降至正常后又反跳者,病情进展较快,预后不良。
Objective To investigate the clinical effect of endocrine therapy on advanced prostate cancer. Methods Twenty-three patients with advanced prostate cancer underwent endocrine therapy (castration and anti-androgen therapy), follow-up symptoms, regression of tumor, periodic review of PSA and liver function, and survival time were recorded. Results After 23 cases of treatment, the first year, 21 patients with PSA decreased to normal. In the second year, 19 were stable and 4 died of the disease. The third year, 12 patients survived, a total of 11 deaths. Conclusions In patients with advanced prostate cancer, the initial reduction of PSA to normal soon after treatment is affirmative, the PSA decreases slowly, and can not be reduced to normal or normal after rebound. The progression of the disease is rapid and the prognosis is poor.