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在大鼠受损坐骨神经上加入 5 μmol L藜芦碱溶液 ,观察到了抛物线簇放电的现象。根据Plant模型 ,发生抛物线簇放电的前提条件必须有两个慢变量所支配的慢振荡过程。结合实验模型 ,从离子通道活动的角度揭示了抛物线簇放电发生的生物物理机制。由藜芦碱诱发的慢变钠内流和钙依赖钾外流被认为是引发实验所观察到的抛物线簇放电的两个慢变量。进而阐明了藜芦碱引起这一放电形式所起的作用 ,即抑制钠通道失活引发慢变钠内流。这种利用非线性动力学理论的分析方法可能会为分析药物的药物动力学提供一种新的途径。
In the rat sciatic nerve damage by adding 5 μmol L veratridine solution, observed parabolic cluster discharge phenomenon. According to the Plant model, the prerequisites for a parabolic cluster discharge must be slow oscillations dictated by two slow variables. Combined with the experimental model, the biophysical mechanism of parabolic cluster discharge was revealed from the perspective of ion channel activity. Slow-thaw sodium influx and calcium-dependent potassium efflux induced by veratridine were considered as two slow variables that initiated the experimentally observed parabolic cluster discharges. Further clarify the role of veratridine caused by this discharge form, that is, inhibition of sodium channel deactivation caused by slowly changing sodium influx. This method of analysis using nonlinear dynamics theory may provide a new way to analyze the pharmacokinetics of drugs.