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目的:观察中西医结合治疗糖尿病周围神经病变的临床疗效。方法:选取120例糖尿病周围神经病变患者,按照随机数字表法随机分为观察组和对照组各60例,对照组给予甲钴胺注射液和注射用鼠神经生长因子治疗,观察组在对照组治疗基础上给予黄芪桂枝五物汤治疗。2组均以30天为1疗程,治疗2疗程。观察2组治疗前后的运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)、多伦多临床评分系统(TCSS)评分,比较2组的临床疗效。结果:治疗1疗程后,观察组总有效率95.00%,显著高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,2组正中神经及腓总神经的MNCV及SNCV均较治疗前改善(P<0.05,P<0.01),观察组改善较对照组更为明显(P<0.05);2组TCSS评分均较治疗前下降(P<0.01),观察组下降较对照组更为明显(P<0.01)。结论:中西医结合治疗糖尿病周围神经病变疗效确切,能有效改善患者的临床症状和体征,值得在临床推广使用。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of diabetic peripheral neuropathy. Methods: 120 patients with diabetic peripheral neuropathy were selected and randomly divided into observation group (60 cases) and control group (60 cases) according to the random number table method. The control group was treated with mecobalamin and injected with nerve growth factor (NGF) On the basis of treatment given astragalus Guizhi Wuwu Tang treatment. 2 groups were 30 days for a course of treatment, treatment 2 courses. The motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV) and Toronto clinical score system (TCSS) scores of two groups before and after treatment were observed. The clinical curative effect was compared between the two groups. Results: After a course of treatment, the total effective rate in the observation group was 95.00%, which was significantly higher than that in the control group (80.00%), the difference was statistically significant (P <0.05). After treatment, the MNCV and SNCV of the median nerve and common peroneal nerve in both groups were improved compared with before treatment (P <0.05, P <0.01), and the improvement in the observation group was more obvious than that in the control group (P <0.05) (P <0.01). The decrease in the observation group was more obvious than that in the control group (P <0.01). Conclusion: Integrative Medicine for the treatment of diabetic peripheral neuropathy exact effect, can effectively improve the clinical symptoms and signs of patients, it is worth promoting in clinical use.