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为探讨正常新生儿和HIE新生儿血浆促红细胞生成素(EPO)及血小板生成素(TPO)的变化规律和临床意义,以29例健康足月儿为对照组,62例HIE患儿为HIE组,轻度HIE30例,中重度HIE组(轻度HIE30例,中重度HIE组32例),分别检测三组新生儿出生后第1、2、7天血浆EPO和TPO水平、血网织红细胞(Ret)计数和动脉血氧分压(PaO2)值。结果显示:与对照组相比,HIE组在生后第1天EPO、TPO、Ret三值较高,其中以中重度组最高,第2天三组三指标开始迅速下降,轻度HIE组下降较慢,中重组最慢。至第7天,HIE组和对照组三指标无显著性差异。生后第1天EPO、Ret与PaO2值呈负相关,EPO和TPO呈正相关,可以认为,EPO和Ret可作为判断新生儿出生前后体内缺氧的指标之一。新生儿HIE时,TPO与EPO在促进红细胞生成方面有协同作用。
To investigate the changes and clinical significance of plasma erythropoietin (EPO) and thrombopoietin (TPO) in normal newborns and neonates with HIE, 29 healthy infants were used as control group, and 62 HIE infants were selected as HIE group , Mild HIE in 30 cases, moderate-severe HIE group (mild HIE in 30 cases, moderate-severe HIE group in 32 cases). The levels of plasma EPO and TPO were detected on the 1st, 2nd, Ret count and arterial partial pressure of oxygen (PaO2) values. The results showed that compared with the control group, the EPO, TPO and Ret values of HIE group were higher on the first postnatal day, especially in the moderate and severe groups. On the second day, the three indexes of the three groups began to decrease rapidly and the HIE group Slower, the slowest in the restructuring. By the 7th day, there was no significant difference between the three indexes of HIE group and control group. On the first day after birth, EPO, Ret and PaO2 values were negatively correlated, EPO and TPO were positively correlated, it can be considered, EPO and Ret can be used as an indicator of neonatal hypoxia before and after birth. Neonatal HIE, TPO and EPO have synergistic effects in promoting erythropoiesis.