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组织因子(tissue factor,TF)亦称为组织凝血活酶,是生理性止、凝血过程及多种病理性血栓形成的启动因子,在动脉粥样硬化、系统性炎症、心绞痛、弥散性血管内凝血、肿瘤的血管发生与转移等多种疾病的形成中发挥重要作用。寻找以TF为靶点的抗凝、抗血栓药物具有重要的理论和现实意义,概述了近年来对血栓形成中TF表达具有调节作用的中药有效成分的研究进展。
Tissue factor (TF), also known as tissue thromboplastin, is a proinflammatory, clotting process and a variety of pathogenic thrombosis initiators, in atherosclerosis, systemic inflammation, angina, diffuse intravascular Coagulation, tumor angiogenesis and metastasis and other diseases play an important role in the formation. The search for anticoagulant and antithrombotic drugs targeting TFs has important theoretical and practical significance. The research progress in the active ingredients of traditional Chinese medicine that has regulatory effect on TF expression in thrombosis in recent years is summarized.