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血清ＨＢｓＡｇ、ＨＢｅＡｇ双阳性母亲的新生儿分别于出生时、１月龄、６月龄各接种１剂２０μｇ乙型肝炎（乙肝）疫苗后随访２ａ。随机抽取母婴乙肝病毒（ＨＢＶ）传播阻断成功的６４例、失败的２９例。用斑点杂交测定孕妇临产时血清ＨＢＶ－ＤＮＡ水平。结果表明疫苗阻断母婴传播成功组孕妇血清ＨＢＶ－ＤＮＡ水平明显低于失败组提示孕妇血清ＨＢＶ－ＤＮＡ水平高可能是疫苗阻断母婴传播失败原因之一。
Serum HBsAg, HBeAg double positive mothers of newborns were at birth, 1 month, 6 months of age were vaccinated with a dose of 20μg Hepatitis B (hepatitis B) vaccine follow-up 2a. A total of 64 cases of successful blockade of HBV transmission in mother and baby were randomly selected and 29 cases failed. Determination of serum HBV-DNA levels in pregnant women during labor with dot blot hybridization. The results showed that the serum HBV-DNA level of pregnant women with successful blockage of mother-to-child transmission was significantly lower than that of the failure group, suggesting that high serum HBV-DNA levels in pregnant women may be one of the reasons for the failure of the vaccine to block mother-to-child transmission.