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目的初步分析丙泊酚和异氟醚对老年脑膜瘤患者的抗炎疗效,观察抗炎性细胞因子白细胞介素13(IL-13)、白细胞介素10(IL-10)及白细胞介素4(IL-4)的改变。方法选择脑膜瘤手术老年患者65例,根据性别随机分为丙泊酚组(33例)和异氟醚组(32例),分别在麻醉诱导前、术后0、24、48 h各抽取静脉血5 m L,检测血清抗炎性因子中IL-13、IL-10和IL-4含量。结果丙泊酚组脑膜瘤老年患者与异氟醚组比较,麻醉诱导前和术后0 h血清IL-13、IL-10和IL-4含量差异均无统计学意义(均P>0.05);术后48 h,丙泊酚组IL-13、IL-10和IL-4含量[分别为(80.69±15.61)、(137.49±25.9)、(65.78±12.40)ng/L]均明显高于异氟醚组[分别为(62.56±12.41)、(112.02±21.82)、(52.45±9.24)ng/L](P<0.05)。结论老年脑膜瘤患者使用丙泊酚比异氟醚吸入能更好地降低术后炎性作用。
Objective To analyze the anti-inflammatory effects of propofol and isoflurane on elderly patients with meningioma and to observe the effects of anti-inflammatory cytokines such as interleukin-13 (IL-13), interleukin 10 (IL-10) and interleukin-4 (IL-4) changes. Methods Totally 65 senile patients with meningioma undergoing surgery were randomly divided into propofol group (33 cases) and isoflurane group (32 cases) according to sex. The venous blood samples were collected before anesthesia induction and 0,24,48 h after operation Blood 5 m L, detection of serum anti-inflammatory cytokines IL-13, IL-10 and IL-4 content. Results Compared with isoflurane group, there was no significant difference of serum IL - 13, IL - 10 and IL - 4 levels between the propofol group and the isoflurane group (all P> 0.05). The levels of IL-13, IL-10 and IL-4 in the propofol group were significantly higher than those in the 48 h group (80.69 ± 15.61, (137.49 ± 25.9) and (65.78 ± 12.40) ng / L, respectively (62.56 ± 12.41, (112.02 ± 21.82) and (52.45 ± 9.24) ng / L, respectively] (P <0.05). Conclusion Propofol and isoflurane inhalation in elderly patients with meningioma can reduce postoperative inflammatory effects better.