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Sparfloxacin(SPFX)是一种新喹诺酮类药.作者以前发现该药在裸鼠实验化疗中的抗麻风菌活性比氟嗪酸强。据此,作者对该药的抗麻风活性作了更详细的研究.实验化疗采用动力法。在第一个实验中,以 SPFX2.5和10mg/kg 剂量,每周5或6次连续管饲,在接种后60～152天给药。第二个实验中为间歇给药,剂量为10和20mg/kg 每周2次或30mg/kg 每周1次管饲,均在接种后61～154天给药。实验动物为5周龄的 BALB/C 雌性裸鼠,随机分组,每组10
Sparfloxacin (SPFX), a new quinolone drug, has previously been shown to have anti-Leprosy activity better than triflumuron in experimental chemotherapy in nude mice. Accordingly, the author of the anti-leprosy activity of the drug made a more detailed study. Experimental chemotherapy using dynamic method. In the first experiment, gavage was administered 5 or 6 weekly doses at SPFX 2.5 and 10 mg / kg doses, 60 to 152 days after vaccination. The second experiment consisted of intermittent dosing of 10 and 20 mg / kg twice weekly or 30 mg / kg gavage weekly for 61 to 154 days after inoculation. The experimental animals were 5-week-old female BALB / C nude mice, randomly assigned to 10 in each group