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目的：探讨急性脑梗塞（ａｃｕｔｅ ｃｅｒｅｂｒａｌ ｉｎｆａｒｃｔｉｏｎ， ＡＣＩ）患者血浆一氧化氮（ｎｉｔｒｉｃ ｏｘｉｄｅ， ＮＯ）、内皮素（ｅｎｄｏｔｈｅｌｉｎ， ＥＴ）与中医血瘀证的关系。方法：７３例ＡＣＩ患者分为血瘀证组５８例（其中重度１８例，中度１９例，轻度２１例）和非血瘀证组１５例，并与３０名健康体检者作对照，测定血浆ＮＯ和ＥＴ含量。结果：血瘀证组、ＡＣＩ组ＥＴ、ＥＴ／ＮＯ均显著高于健康对照组（Ｐ＜０．０１）；血瘀证组轻、中、重度组ＥＴ、ＥＴ／ＮＯ依次增高，重度组与轻、中度组比较有显著性差异（Ｐ＜０．０），中度组与轻度组比较仅ＥＴ有显著性差异（Ｐ＜０．０１）；ＡＣＩ组、血瘀证组、非血瘀证组ＮＯ含量与健康对照组比较均显著降低（Ｐ＜０．０５，Ｐ＜０．０１）；血瘀证轻、中、重度各组间ＮＯ含量比较无显著性差异（Ｐ＞ ０．０５）。结论：ＮＯ和ＥＴ参与了ＡＣＩ发展过程，推测由于血管及神经细胞等分泌ＮＯ、ＥＴ的功能失衡可能是血瘀证产生的病理基础。
Objective: To investigate the relationship between plasma nitric oxide (NO), endothelin (ET) and blood stasis syndrome in patients with acute cerebral infarction (ACI). Methods: Seventy-three patients with ACI were divided into 58 cases (including 18 cases of moderate and severe, 19 cases of mild and 21 cases of mild blood stasis syndrome) and 15 cases of non-blood stasis syndrome, and compared with 30 healthy subjects, Plasma NO and ET levels. Results: The levels of ET and ET / NO in blood stasis syndrome group and ACI group were significantly higher than those in healthy control group (P <0.01) There was significant difference between mild group and moderate group (P <0.0), ET only had significant difference between moderate group and mild group (P <0.01); ACI group, blood stasis group, There was no significant difference in the content of NO in blood stasis syndrome group compared with the healthy control group (P <0.05, P <0.01). 05). CONCLUSION: NO and ET are involved in the development of ACI. It is speculated that due to the secretion of nitric oxide (NO) from blood vessels and nerve cells, imbalance of ET may be the pathological basis of blood stasis syndrome.