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目的探讨乙型肝炎肝硬化患者的负性情绪对血清促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)及神经肽Y(neuropeptide Y,NPY)的影响。方法将617例乙型肝炎肝硬化患者按照负性情绪的判定方法分为负性情绪组(415例)和无负性情绪组(202例),记录两组患者Child-Pugh不同分级例数,比较两组患者肝功能情况;采用双抗体一步夹心法酶联免疫吸附试验(ELISA)检测两组患者血清ACTH、NPY水平。结果负性情绪组Child-Pugh分级与无负性情绪组比较,差异无统计学意义(x~2=0.65,P=0.72);与无负性情绪组比较,负性情绪组血清NPY水平明显降低,差异有统计学意义(P<0.05),两组ACTH水平比较,差异无统计学意义(P>0.05)。结论本研究纳入的乙型肝炎肝硬化患者的负性情绪与血清ACTH水平无关,与相对低浓度的血清NPY水平有关。
Objective To investigate the effect of negative emotions on serum adrenocorticotropic hormone (ACTH) and neuropeptide Y (NPY) in patients with hepatitis B cirrhosis. Methods Six hundred and seventy-seven patients with hepatitis B cirrhosis were divided into negative emotion group (415 cases) and negative emotion group (202 cases) according to the negative emotion determination method. The Child-Pugh different grading cases, The liver function of the two groups was compared. The levels of ACTH and NPY in the two groups were detected by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results There was no significant difference in Child-Pugh grading between negative emotion group and negative emotion group (x ~ 2 = 0.65, P = 0.72). Compared with negative emotion group, the serum NPY level in negative emotion group was significantly (P <0.05). There was no significant difference in ACTH levels between the two groups (P> 0.05). Conclusions The negative emotions of patients with hepatitis B cirrhosis included in this study have nothing to do with serum ACTH levels, which is associated with a relatively low serum NPY level.