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最近一些研究表明,根除幽门螺旋菌(HP)可使十二指肠溃疡(DU)患者增高了的餐后胃泌素水平降低,但并未述及这种变化是否系治疗HP感染药物本身的作用。在DU患者,由胃泌素释放肽所致的胃泌素释放是否也受根除HP的影响亦不清楚。本文研究HP的根除治疗是否同时降低蛙皮素刺激的胃泌素释放,是否影响胃窦G细胞的功能,还观察了HP阳性者口服尿素前后胃泌素的释放情况。用~(13)C-尿素呼吸试验和检测抗HP高分子量细胞相关蛋白质IgG抗体以确定有无HP感染。HP阳性DU患者18例,HP阴性无症状健康志愿者(对照组)8例。抽取空腹静脉血10ml,将蛙皮素溶解在0.25％白蛋白盐水中持续输注;每30min抽血10ml,用放免法测定血清胃泌素含量。每例病人进行为期10天的三联抗菌治疗(四环素、甲硝唑、铋剂)。停药后3～24天重复前述胃泌素测定。细菌培养、组织学检查、呼吸试验在停药一个月后仍保持阴性者为HP根除。 DU患者的空腹血清胃泌素含量显著高于HP阴
Recent studies have shown that the eradication of Helicobacter pylori (HP) can reduce the elevated postprandial gastrin levels in patients with duodenal ulcer (DU), but does not say whether this change is the treatment of HP-infected drug itself effect. It is unclear whether the release of gastrin by gastrin-releasing peptides is also affected by eradication of HP in DU patients. This article studies whether eradication therapy of HP can simultaneously reduce the release of gastrin stimulated by bombesin and affect the function of G cells in gastric antrum, and also observe the release of gastrin before and after administration of urea by HP. The ~ (13) C-urea breath test and the detection of anti-HP high molecular weight cell-associated protein IgG antibodies were used to determine the presence or absence of HP infection. 18 cases of HP-positive DU patients and 8 cases of HP-negative asymptomatic healthy volunteers (control group). Fasting venous blood was drawn 10ml, the bombesin dissolved in 0.25% albumin saline continuous infusion; blood draw 10ml every 30min, radioimmunoassay determination of serum gastrin levels. Each patient was given a triple antimicrobial treatment for 10 days (tetracycline, metronidazole, bismuth). The gastrin assay was repeated 3 to 24 days after stopping the drug. Bacterial culture, histology, and respiratory tests remained negative for HP after one month of discontinuation. The fasting serum gastrin level in DU patients was significantly higher than that in HP patients