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目的进行乙酰地蒽酚软膏在小型猪皮肤的急性毒性试验,为乙酰地蒽酚软膏进行长期毒性剂量设计和对临床安全用药提供参考信息。方法 8只普通级巴马小型猪,分为四组,分别为正常皮肤对照组、破损皮肤对照组、正常皮肤给药组、破损皮肤给药组,每组2例,且每组雌雄各半,除常规指标外,对其进行体温、血液生化、心电图等指标的观察。结果与对照组比较,正常皮肤给药后皮肤刺激性较轻,主要为皮肤发红;破损皮肤给药后皮肤刺激性较重,可见发红、发黑等,上述刺激性可自行好转或恢复。血液生化指标可见一定的伴随性改变。结论乙酰地蒽酚软膏急性毒性实验中小型猪破损皮肤对照组刺激性较正常皮肤给药组明显,但均有较好的可逆性。
OBJECTIVE To study the acute toxicity test of anthracene phenol ointment on the skin of miniature pigs and to provide long-term toxic dose design for the anthracene phenol ointment and to provide reference information for clinical safe drug use. Methods Eight normal Bama miniature pigs were divided into four groups: normal skin control group, damaged skin control group, normal skin administration group and damaged skin administration group, with 2 cases in each group , In addition to conventional indicators, the body temperature, blood biochemistry, ECG and other indicators of observation. Results Compared with the control group, the irritation of the skin after normal skin administration was light, mainly due to redness of the skin; skin irritation was severe after the damaged skin was administered, showing redness and blackness. The above irritation could be improved or recovered by itself . Biochemical indicators of blood can be seen some concomitant changes. Conclusion Acetodanthenil ointment acute toxicity test in mini-pig damaged skin irritation control group than the normal skin group was significantly, but both have good reversibility.