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目的：研究孕期弓形体感染胎、婴儿的结局，母婴传播途径及治疗。方法：应用ＥＬＩＳＡＩｇＭ方法筛查３８７８例孕妇弓形体近期感染情况。追踪８２例弓形体近期感染孕妇分娩的胎、婴儿预后、收集脐血、羊水、胎盘及尸解的器官组织了解母婴传播途径及病理改变。观察应用螺旋霉素系统治疗孕期弓形体感染者的胎、婴儿预后，并与未治疗组对照。结果：本组孕妇弓形体近期感染发生率为４．４１％（１７１／３８７８），其胎、婴儿出现临床症状为３０．４８％（２５／８２）；孕早期感染以畸胎、流产多见，孕晚期感染表现为早产、低体重儿、黄疸及弓形体感染性肺炎等。从胎盘、羊水、脐血及尸解器官组织中可查出弓形体ＤＮＡ。显示弓形体可通过胎盘感染胎儿，严重者造成器官损害。应用螺旋霉素治疗孕期弓形体感染有效。治疗组先天性弓形体感染发生率低于对照组（Ｐ＜０．０１）。结论：孕妇近期弓形体感染可通过胎盘感染胎儿，造成畸胎、流产、早产、低体重儿及急性弓形体感染症状。螺旋霉素治疗孕期弓形体感染有效。
Objective: To study the status of Toxoplasma infection during pregnancy, infant outcome, mother-infant transmission and treatment. Methods: The ELISA method was used to screen 3878 cases of toxoplasma recent infection. 82 cases of Toxoplasma gonads recently infected pregnant women delivery of the fetus, infant prognosis, cord blood collection, amniotic fluid, placenta and autopsy of organ tissue to understand the mother-to-child transmission and pathological changes. To observe the application of spiramycin system during pregnancy Toxoplasma gondii pregnancy, infant prognosis, and untreated group control. Results: The incidence of Toxoplasma gondii infection in late pregnancy was 4.41% (171/3878). The clinical symptoms of fetuses and infants were 30.48% (25/82) , Third trimester infection showed premature delivery, low birth weight, jaundice and toxoplasmosis pneumonia. From the placenta, amniotic fluid, cord blood and autopsy organs can be found in Toxoplasma DNA. Toxoplasma can be shown through the placenta infect the fetus, severe organ damage. Spiramycin treatment of Toxoplasma infection during pregnancy effective. The incidence of congenital toxoplasma in treatment group was lower than that in control group (P <0.01). Conclusion: The recent infection of Toxoplasma by pregnant women can infect the fetus through the placenta, resulting in the symptoms of teratogenic, abortion, premature birth, low birth weight and acute toxoplasmosis. Spiramycin treatment of toxoplasma infection during pregnancy effective.