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目的为了解国内文献报道的疫苗相关麻痹型脊髓灰质炎病例(Vaccine-associated paralytice poliomyelitis,VAPP)发病情况及流行病学特征,探讨VAPP发生的危险因素,为预防接种人员提供接种依据,同时为疑似预防接种异常反应专家组诊断提供参考。方法采用描述流行病学方法对国内文献报道的1980~2012年发生的188例VAPP进行分析。结果发病年龄以≤6月龄为主,占病例总数的66.4%,男女比为3∶1,首次服苗病例数为再次服苗的3.24倍,病毒分型以Ⅱ型为主。结论在我国维持无脊灰阶段,减少VAPP发生成为消灭脊灰的重要内容之一,应引起高度重视。
Objective To understand the incidence and epidemiological characteristics of vaccine-associated paralytice poliomyelitis (VAPP) reported in the domestic literature and to explore the risk factors for VAPP and to provide basis for vaccination against vaccination, Vaccination expert group for diagnosis of abnormal response to provide a reference. Methods Descriptive epidemiological methods were used to analyze 188 VAPP cases reported in the domestic literature from 1980 to 2012. Results The age of onset was ≤ 6 months old, accounting for 66.4% of the total number of cases. The ratio of male to female was 3:1. The number of cases of first dose of vaccine was 3.24 times of that of the second dose of vaccine. The type of virus was mainly type Ⅱ. Conclusions In our country, to maintain the stage of polio-free and reduce the incidence of VAPP as one of the important contents of polio eradication should be given high priority.