论文部分内容阅读
病原体感染或抗原刺激可诱导树突状细胞 (DC)分化为DC1和DC2并迁移进入淋巴组织 ,在淋巴组织中 ,DC1和DC2通过抗原特异性信号 (递呈抗原 )、协同刺激信号 (诱导Th充分活化 )和分化或极化信号 (主要是IL 12 ,也包括DC的表面分子 )分别诱导Th分化为Th1和Th2 ,各种抗原相关的、感染组织相关的和免疫相关的因素通过调节IL 12的分泌水平和协同刺激分子的表达水平 ,或调节Th对DC的敏感性而调控Th的分化。这些相互作用使机体能快速选择合适的免疫应答方式清除相应的抗原。本文介绍了DC诱导Th分化机理的最新进展
Pathogen infection or antigen stimulation can induce dendritic cells (DCs) to differentiate into DC1 and DC2 and migrate into lymphoid tissue where DC1 and DC2 co-stimulate signals (inducing Th Fully activated) and differentiated or polarized signals (primarily IL 12, also surface molecules including DC) induce Th differentiation into Th1 and Th2, respectively. Various antigen-related, tissue-associated and immune-related factors of infection are mediated by modulation of IL 12 Secretion and co-stimulatory molecules, or regulate Th sensitivity to DC to regulate Th differentiation. These interactions allow the body to quickly select the appropriate immune response to clear the corresponding antigen. This article describes the latest progress in the mechanism of DC-induced Th differentiation