论文部分内容阅读
目的分析甲状腺结节良性疾病采用左旋甲状腺组抑制疗法治疗的临床效果。方法以80例甲状腺结节良性疾病患者为研究对象,将患者随机平均分为观察组和对照组,对照组接受安慰剂治疗,观察组接受左旋甲状腺素治疗,对比两组患者甲状腺结节变化情况及不良反应。结果观察组甲状腺结节缩小24例,对照组4例,两组比较差异有统计学意义(P<0.05)。治疗前两组甲状腺结节体积和促甲状腺激素(TSH)水平比较差异未见统计学意义;治疗后观察组甲状腺结节体积和TSH水平低于对照组,且低于治疗前水平(均P<0.05)。对照组治疗前后甲状腺结节体积和TSH水平比较差异未见统计学意义。观察组5例患者服药期间出现不良反应,不良反应发生率为12.5%,分别为心悸2例,胸闷2例,震颤1例,无凝血功能异常和Graves病例。结论短期小剂量左旋甲状腺素抑制治疗甲状腺结节良性疾病的疗效显著,可有效阻止组织结节发展,且安全性好。
Objective To analyze the clinical effect of thyroid nodule benign disease treated with anti-thyroid therapy. Methods Eighty patients with benign thyroid nodules were enrolled. The patients were randomly divided into observation group and control group. The control group received placebo and the observation group received levothyroxine. The changes of thyroid nodules in two groups were compared And adverse reactions. Results In the observation group, thyroid nodules were reduced in 24 cases and in control group in 4 cases. There was significant difference between the two groups (P <0.05). Thyroid nodule volume and thyroid stimulating hormone (TSH) levels were not significantly different between the two groups before treatment; thyroid nodule volume and TSH level in the observation group after treatment were lower than those in the control group, and were lower than those before treatment (all P < 0.05). The thyroid nodule volume and TSH level in the control group before and after treatment showed no significant difference. In the observation group, 5 patients showed adverse reactions during the course of medication, with a rate of adverse reactions of 12.5%, including 2 cases of palpitations, 2 cases of chest tightness, 1 case of tremor and no coagulation abnormalities and Graves’ cases. Conclusion Short-term low-dose levothyroxine suppresses the benign thyroid nodules and has a good curative effect. It can effectively prevent the development of tissue nodules and has good safety.