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冠心病心绞痛患者29例(男性19例,女性10例;年龄56±10a)接受尼卡地平与安慰剂双盲对照试验,20例服尼卡地平20mg, tid, po;9例服安慰剂;均服4wk。该29例治疗前红细胞内铜含量与13例正常人相同,锌含量明显高于正常人。20例经尼卡地平治疗后红细胞内锌含量明显下降(P<0.05),9例服安慰剂治疗后锌、铜含量无变化。相关分析表明红细胞内锌含量与血清高密度脂蛋白呈负相关;与甘油三酯呈正相关。
A total of 29 patients with coronary heart disease (19 males, 10 females; 56 ± 10 years of age) received a controlled double-blind controlled trial of nicardipine and placebo, 20 received nicardipine 20 mg, tid, po and 9 received placebo. Serve 4wk. The 29 cases of pretreatment erythrocyte copper content and 13 normal subjects the same, zinc content was significantly higher than normal. The content of zinc in erythrocytes of 20 patients treated with nicardipine was significantly decreased (P <0.05), while the contents of zinc and copper in 9 patients treated with placebo remained unchanged. Correlation analysis showed that zinc content in erythrocytes was negatively correlated with serum high density lipoprotein, and positively correlated with triglyceride.