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目的:观察“健脾益气、解毒祛瘀法”联合FOLFOX4方案治疗晚期大肠癌的临床疗效。方法:将60例晚期大肠癌患者随机分为两组,各30例,治疗组采用“健脾益气、解毒祛瘀法”联合FOLFOX4方案治疗,对照组单独采用FOL-FOX4方案治疗。结果:肿瘤客观疗效比较:治疗组的有效率为70%,对照组的有效率为63.3%,两组比较无显著性差异(P>0.05);两组患者化疗引起的毒副反应比较:治疗组患者的白细胞和血小板减少程度较轻微,对照组患者的白细胞和血小板减少程度较重,两组比较有显著性差异(P<0.05);治疗组恶心呕吐的程度也较轻,而对照组恶心呕吐的程度较重,从I级到Ⅳ级均有发生,以中度呕吐为主,并有3例为难治性呕吐(Ⅳ级),两组比较有显著性差异(P<0.05)。两组患者均无发热现象;治疗前后KPS评分的比较:两组病人治疗前KPS评分比较无显著性差异(P>0.05);治疗后KPS评分比较治疗组高于对照组,说明治疗组病人生活质量高于对照组(P<0.01)。结论:“健脾益气、解毒祛瘀法”联合FOLFOX4方案治疗晚期大肠癌能取得较好的临床疗效,减轻化疗毒副反应,明显改善患者的生活质量。
Objective: To observe the clinical efficacy of “Spleen Qi, detoxification and stasis method” combined with FOLFOX4 regimen in the treatment of advanced colorectal cancer. Methods: Sixty patients with advanced colorectal cancer were randomly divided into two groups (n = 30 in each group). The treatment group was treated with FQ-FOX4 regimen in combination with FQFX4. Results: Comparison of objective curative effect of the tumor: the effective rate of the treatment group was 70%, the effective rate of the control group was 63.3%, there was no significant difference between the two groups (P> 0.05); Comparison of the side effects caused by chemotherapy in the two groups: The leukopenia and thrombocytopenia in the control group were less severe than those in the control group, and the leukopenia and thrombocytopenia in the control group were more severe (P <0.05). The degree of nausea and vomiting was also lighter in the treatment group, while the nausea and vomiting in the control group The degree of vomiting was heavier, from grade I to grade IV, with moderate vomiting, and three cases with refractory vomiting (grade IV). There was significant difference between the two groups (P <0.05). There was no fever in both groups. Comparison of KPS scores before and after treatment showed no significant difference in KPS scores before and after treatment (P> 0.05). After treatment, KPS score was higher in the treatment group than in the control group, indicating that patients in the treatment group were living The quality was higher than that of the control group (P <0.01). Conclusion: “Spleen Qi, detoxification and stasis method” combined with FOLFOX4 regimen for advanced colorectal cancer can achieve better clinical efficacy, reduce chemotherapy side effects, and significantly improve the quality of life of patients.