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应用银染-G带复合显示方法研究了肺癌、胃癌、肠癌、乳腺癌患者的外周淋巴细胞核仁形成区(NOR)活性。与正常对照相比,肺癌第15号染色体的Ag-NOR频率及Ag-NOR总频率增加,乳腺癌第14号染色体的Ag-NOR频率减少,胃癌第14号染色体Ag-NOR频率减少而第22号染色体的Ag-NOR频率增加。肠癌未见明显变异。结果提示不同部位的肿瘤具有不同的优势银染型,rRNA基因的表达可能存在肿瘤部位的特异性。
The peripheral lymphocyte nucleolar organizer region (NOR) activity of lung cancer, gastric cancer, intestinal cancer and breast cancer patients was studied by silver staining-G complex display method. Compared with the normal control, Ag-NOR frequency and Ag-NOR frequency of lung cancer chromosome 15 increased, the frequency of Ag-NOR decreased on chromosome 14 of breast cancer, the frequency of Ag-NOR decreased on chromosome 14 of gastric cancer, Chromosomal Ag-NOR frequency increased. No significant changes in intestinal cancer. The results suggest that different parts of the tumor has different advantages of silver staining, rRNA gene expression may exist tumor site specificity.