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十多年来,已认识到在一些冠状动脉造影正常的病人中心肌亦可发生缺血,甚至梗死。此种情况可见于年轻的男女,一些患者为13~19岁。早在1939年Friedberg和Horn就曾报道过在冠状动脉无闭塞情况下发生的急性心肌梗死。心肌缺血的病因在病理学上可根据冠状动脉健康与否(最通常为粥样硬化)来分类。冠状动脉正常而发生心肌缺血的三个重要因素是冠状血流减少、贫血所致心肌缺氧、高血压或心脏活动过度(Hyperkinetic)引起心脏负担过重。冠状血流可因肺血管阻力增高而减少,结果左心供血不
For more than a decade, it has been recognized that ischemic or even infarction can occur in the myocardium of some patients with normal coronary angiography. This situation can be seen in young men and women, some patients 13 to 19 years old. As early as 1939, Friedberg and Horn reported acute myocardial infarction in the absence of occlusion of the coronary arteries. The etiology of myocardial ischemia can be classified histologically based on coronary artery health (most commonly atherosclerosis). Three important factors that cause normal myocardial ischemia and myocardial ischemia are coronary blood flow reduction, myocardial hypoxia caused by anemia, hypertension or hyperkinetic overload of the heart. Coronary blood flow may be due to increased pulmonary vascular resistance decreased, the results of left ventricular blood supply is not