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甲苯在工业上被广泛地用作溶剂,现已证实甲苯对大鼠有一定的毒性作用。在吸入实验中,可以引起大鼠持续性的高频听力损伤。噪声也可引起人和实验动物的高频听力损失。临床观察到在有噪声又有有机溶剂的环境中工作的工人有着比仅受噪声影响的工人更严重的听力损失。作者将大鼠分别暴露在噪声、甲苯及甲苯后再给噪声的条件下,观察听觉脑干反应的阈值、潜伏期和波间期的变化,动物分成四组:T 组12只仅暴露在甲苯中,浓度为1000ppm,每天10小时,每周5天共2周,暴露后2～5天记录 ABR,1个月和6个月后再观察
Toluene is widely used as a solvent in industry and toluene has been shown to have some toxic effects on rats. In inhalation experiments, can cause persistent high-frequency hearing loss in rats. Noise can also cause high frequency hearing loss in humans and laboratory animals. It is clinically observed that workers who work in a noisy and organic solvent environment have more severe hearing loss than workers who are only affected by noise. After exposing rats to noise, toluene and toluene respectively and then giving noise, the threshold, latency and wave interval of auditory brainstem response were observed. The animals were divided into four groups: T group 12 was only exposed to toluene , The concentration of 1000ppm, 10 hours a day, 5 days a week for 2 weeks, 2 to 5 days after exposure recorded ABR, 1 and 6 months after the observation