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[目的]探讨经支气管动脉灌注化疗联合立体定向适形放疗治疗中晚期中央型肺癌的疗效。[方法]79例中晚期中央型肺癌患者随机分为联合放疗组和单纯介入组,行经支气管动脉灌注化疗,术后联合放疗组行立体定向适形放疗,观察两组治疗效果。[结果]联合放疗组和单纯介入组有效率分别为70.0%(28/40)和43.6%(17/39),两组比较有显著性差异(χ2=5.618,P=0.018)。联合放疗组消化道症状、骨髓抑制发生率均高于单纯介入组(47.5%vs20.5%,P=0.011;37.5%vs15.4%,P=0.026),但均可耐受;联合放疗组急性放射性毒副反应较轻。[结论]经支气管动脉灌注化疗联合立体定向适形放疗治疗中晚期中央型肺癌疗效优于单纯介入治疗,且毒副反应可耐受。
[Objective] To investigate the efficacy of transcatheter arterial infusion chemotherapy combined with stereotactic conformal radiotherapy in the treatment of advanced central lung cancer. [Method] A total of 79 patients with central and advanced stage central lung cancer were randomly divided into combined radiotherapy group and simple interventional group. After bronchial artery infusion chemotherapy, combined with radiotherapy group underwent stereotactic conformal radiotherapy. The therapeutic effect was observed in both groups. [Results] The effective rate was 70.0% (28/40) and 43.6% (17/39) in the combined radiotherapy group and the simple intervention group, respectively. There was significant difference between the two groups (χ2 = 5.618, P = 0.018). The incidences of gastrointestinal symptoms and bone marrow suppression in the combined radiotherapy group were significantly higher than those in the simple intervention group (47.5% vs20.5%, P = 0.011; 37.5% vs15.4%, P = 0.026) Acute radioactive side effects lighter. [Conclusion] Transbronchial arterial infusion chemotherapy combined with stereotactic conformal radiotherapy in the treatment of advanced central lung cancer is more effective than simple interventional therapy, and the toxicity can be tolerated.