c-di-GMP是一个在细菌中普遍存在的环核苷酸第二信使分子,广泛调控多种细菌生理活动,包括生物被膜形成、毒力、运动以及细胞分化等.本文总结了c-di-GMP信号系统近期的研究进展,包括调控胞内c-di-GMP水平的上游信号、受c-di-GMP调控的下游受体以及c-di-GMP与真核生物的相互作用.这些新的发现丰富了我们对于c-di-GMP调控机制多样性的理解,也为认识c-di-GMP信号系统在人病原菌结核分枝杆菌中的潜在角色提供了重要线索. c-di-GMP is a second cyclic messenger molecule widely existing in bacteria and widely regulates a variety of bacterial physiological activities including biofilm formation, virulence, exercise and cell differentiation.This paper summarizes c-di Recent advances in the GMP signaling system include upstream signals that regulate intracellular c-di-GMP levels, downstream receptors that are c-di-GMP regulated, and c-di-GMP interact with eukaryotes Has enriched our understanding of the diversity of c-di-GMP regulatory mechanisms and provided important clues for understanding the potential role of c-di-GMP signaling in human pathogenic M. tuberculosis.