西维来司钠是新型人工合成的中性粒细胞弹性蛋白酶抑制剂,它在神经保护方面的研究是一个新的领域。研究表明,西维来司钠能够选择性的抑制中性粒细胞弹性蛋白酶(NE)的释放,抑制炎细胞浸润和中性粒细胞活化,减少炎性介质的释放,以各种途径参与颅脑以及脊髓损伤有的神经保护作用,具有良好的临床应用前景。本文将对其生物活性和神经保护作用方面的研究作一综述。 Celecoxib is a new synthetic neutrophil elastase inhibitor, and its research on neuroprotection is a new field. Studies have shown that sivelestat sodium can selectively inhibit the release of neutrophil elastase (NE), inhibit inflammatory cell infiltration and neutrophil activation, reduce the release of inflammatory mediators, a variety of ways to participate in the brain As well as spinal cord injury and some neuroprotective effect, has good clinical application prospects. This article will review its biological activity and neuroprotection.