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目的探索胃癌、慢性胃病患者脾证分型与 cyclin E 表达的关系.方法在胃癌和慢性胃病患者中,选取具有中医脾虚表现的脾气(阳)虚、脾阴虚患者,和具有脾实表现的脾胃湿热、寒湿困脾证患者,以及按慢性浅表性胃炎、肠上皮化生、不典型增生、胃癌分组的患者,进行胃粘膜组织 cyclin E 免疫组化染色;对各证型的 cyclin E 表达进行比较,并分析 cyclin E 在常见胄粘膜病变中表达的差异.结果 cyclin E 在上述四种脾证分型的表达有显著性差异,阳性百分率分别为7.9%,27.3%,31.4%和14.3%.在慢性浅表性胄炎、肠上皮化生、不典型增生和胃癌的表达也有显著性差异,阳性率分别为7.5%,28.6%,37.9%和42.6%,后两者已较接近.结论胃癌和慢性胃病患者中,不同的中医脾证其 cyclin E 表达明显不同,在脾胃湿热和睥阴虚证型中较高,在寒湿困脾和脾气(阳)虚证型中较低.cyclin E 表达随病变由慢性浅表性胃炎、癌前病变到癌而逐渐增高,其与胃癌的发生发展密切相关.
Objective To explore the relationship between the syndrome differentiation of spleen syndrome and the expression of cyclin E in patients with gastric cancer and chronic gastritis.Methods The patients with gastric cancer and chronic gastritis were selected with the symptoms of spleen deficiency (yang) Gastric mucosa, patients with spleen-stomach damp-heat and cold-dampness and spleen-qi syndrome, as well as patients with chronic superficial gastritis, intestinal metaplasia, dysplasia and gastric cancer. The expressions of cyclin E , And analyze the difference of cyclin E expression in the common mucosal lesions.Results The expression of cyclin E in the above four spleen syndromes was significantly different with the positive rates of 7.9%, 27.3%, 31.4% and 14.3 % .In chronic superficial sargitis, the expression of intestinal metaplasia, dysplasia and gastric cancer were also significantly different, the positive rates were 7.5%, 28.6%, 37.9% and 42.6% respectively, the latter two were close. Conclusions Among patients with gastric cancer and chronic gastritis, the expressions of cyclin E in different TCM syndromes are obviously different, which are higher in damp-heat of the spleen and stomach and yin-deficiency syndrome, and lower in the symptoms of cold-dampness and qi deficiency. The expression of cyclin E varies with chronic superficial lesions Gastritis, precancerous lesions to cancer and gradually increased, it is closely related to the development of gastric cancer.