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通过环境香烟烟雾（ＥＳＴ）模型，观察大鼠碘代谢及甲状腺超微结构变化的结果表明：ＥＳＴ接触组肝脏和粪碘含量增高，血、尿及甲状腺碘含量下降；甲状腺滤泡上皮细胞膜完整性缺损和变形，以上变化均与接触时间有关。提示：ＥＳＴ对机体碘摄取和吸收有抑制作用。接触组肝碘含量异常增高，可能与肝中５′脱碘酶活性受抑制有关。ＥＳＴ有可能是碘缺乏病流行的危险因素之一。
Through the model of environmental cigarette smoke (EST), the changes of iodine metabolism and thyroid ultrastructure in rats were observed. The results showed that the contents of liver and excretion of iodine increased, the contents of iodine and iodine in blood, urine and thyroid decreased in EST exposure group. The membrane integrity of thyroid follicular epithelial cells Defect and deformation, the above changes are related to the contact time. Tip: EST on the body of iodine uptake and absorption inhibited. In the exposure group, the content of liver iodine increased abnormally, which may be related to the inhibition of 5’-deiodinase activity in the liver. EST may be one of the risk factors for the prevalence of iodine deficiency disorders.