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目的:建立脑动静脉畸形(AVM)的病理生理学模型,检测血液动力学改变。方法:将大鼠左侧颈外静脉与颈总动脉行端侧吻合,结扎吻合口近尾端的颈总动脉,测定吻合前后及模型动物饲养16周后的局部脑血流量、右侧颈外静脉压力、颈总动脉压力、颈总动脉的血流速度。结果:大鼠静脉动脉的端侧吻合形成动静脉分流,左侧局部脑血流量显著降低,右侧颈外静脉压增加,颈总动脉压降低,顿总动脉血流速度增快。16周后,局部脑血流量较动静脉吻合形成即刻升高,右侧颈外静脉压和颈总动脉血流速度进一步增高,右侧颈总动脉压无明显改变。结论:大鼠颈部动脉分流形成低灌注压、高血流量、静脉高压的模型,符合AVM的血液动力学特征。长期的脑低灌注压使脑血管反应改变,脑血流量有所增加。
Objective: To establish a pathophysiological model of cerebral arteriovenous malformation (AVM) to detect hemodynamic changes. Methods: The left external jugular vein and common carotid artery were anastomosed and the common carotid artery was ligated proximal to the anastomosis. The regional cerebral blood flow was measured before and after anastomosis and 16 weeks after model animals were fed. The right external jugular vein Pressure, carotid artery pressure, carotid artery blood flow velocity. Results: Arteriovenous shunt was formed by anastomosis of venous artery in rats. The left partial cerebral blood flow decreased significantly. The right external jugular venous pressure increased. The common carotid artery pressure decreased and the total arterial blood flow increased rapidly. After 16 weeks, local cerebral blood flow increased immediately after arteriovenous anastomosis, right external jugular venous pressure and common carotid artery blood flow velocity increased further, and right common carotid artery pressure did not change significantly. Conclusion: The model of shunting of the neck artery of rats with hypoperfusion, high blood flow and venous hypertension is in accordance with the hemodynamic characteristics of AVM. Long-term cerebral hypoperfusion pressure changes of cerebrovascular response, cerebral blood flow has increased.