Objective:To test whether Shenfu Injection(参附注射液,SFI)might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest(CA).Methods:Thirty-four Wuzhishan miniature inbred pigs were randomly divided into three groups:the SFI group(n=12),the saline group(SA group,n=12),and the sham-operated group(sham group,n=10).Following successful return of spontaneous circulation(ROSC)from 8-min untreated ventricular fibrillation,animals received a continuous infusion of either SFI(0.2 mL/min)or saline for 6 h.Cerebral performance category score was evaluated at 24and 48 h after ROSC,followed by positron emission tomography and computed tomography scans of cerebral glucose uptake.Surviving pigs were euthanized 48 h after ROSC,and the brains were removed for detecting mitochondrial function.Results:Compared with the SA group,SFI treatment produced a better neurologic outcome48 h after ROSC(P<0.05).However,there was no significant difference of survival rate between the SA and SFI groups(83.3%vs.81.8%,P>0.05).After ROSC,the SA group showed a decrease in the maximum standardized uptake value of different regions in the brain tissue,where SFI treatment can ameliorate these decreases(P<0.01or P<0.05).Improved mitochondrial respiratory properties and higher mitochondrial membrane potential were also found following SFI treatment compared with the SA group at 48 h after ROSC(P<0.05 or P<0.01).Conclusion:SFI treatment after resuscitation has significant neuroprotective effects against disruption of cerebral energy metabolism from CA by improving glucose uptake and by normalizing mitochondrial function. Objective: To test whether Shenfu Injection (SFI) might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest (CA). Methods: Thirty-four Wuzhishan miniature inbred pigs were randomly divided into three groups: the SFI group (n = 12), the saline group (SA group, n = 12), and the sham- operated group (sham group, n = 10) .Following successful return of spontaneous circulation (ROSC) min untreated ventricular fibrillation, animals received a continuous infusion of either SFI (0.2 mL / min) or saline for 6 h.Cerebral performance category score was evaluated at 24 and 48 h after ROSC, followed by positron emission tomography and computed tomography scans of cerebral glucose uptake. Surviving pigs were euthanized 48 h after ROSC, and the brains were removed for detecting mitochondrial function. Results: Compared with the SA group, SFI treatment produced a better neurologic outcome 48 h after ROSC (P <0.05) .However, there was no significant difference of surv After the SA group showed a decrease in the maximum standardized uptake value of different regions in the brain tissue, where SFI treatment can ameliorate these decreases (P <0.01or P <0.05) .Improved mitochondrial respiratory properties and higher mitochondrial membrane potential were also found following SFI treatment compared with the SA group at 48 h after ROSC (P <0.05 or P <0.01) .Conclusion: SFI treatment after resuscitation has significant neuroprotective effects against disruption of cerebral energy metabolism from CA by improving glucose uptake and by normalizing mitochondrial function.