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在31只人工呼吸制动的家兔申,电刺激脑桥被盖网状结构一定区域(P12.5,L1.8,H—4～-6.8),观察到26只动物有胆囊压力升高。刺激14s后胆囊压力开始上升,1min达到最高值(p<0.01),停刺激0.5min后逐渐回降,2.5min恢复到对照水平。在该区微量注射L-谷氨酸钠也引起胆囊压力升高(p<0.01)。电刺激引起的胆囊压力升高效应不受静脉注射阿托品和心得安的影响,但可被酚妥拉明显著减弱(p<0.01)。结果提示,在刺激脑桥被盖网状结构引起胆囊压力升高的机制中,交感神经和α受体可能是传出途径之一。
In 31 rabbits with artificial respiration bradycardia, electrical stimulation of the pons in a certain area of the reticular network (P12.5, L1.8, H-4 ~ -6.8) was observed in 26 animals with increased gallbladder pressure. Gall bladder pressure began to rise after 14s of stimulation, reached the highest value at 1min (p <0.01), stopped gradually after 0.5min of stimulation and returned to the control level at 2.5min. Microinjection of sodium L-glutamate in this area also caused an increase in gallbladder pressure (p <0.01). The effects of electrical stimulation on the increase of gallbladder pressure were not affected by intravenous atropine and propranolol, but were significantly attenuated by phentolamine (p <0.01). The results suggest that sympathetic and alpha receptors may be one of the efferent pathways in the mechanism of stimulating the increase of gallbladder pressure in the pontine reticular network.