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真核细胞组蛋白 N端赖氨酸残基的乙酰化与基因的转录激活有关。多种具有组蛋白乙酰化酶 (HAT)和组蛋白去乙酰化酶 (HDAC)活性的调节因子 ,通过对组蛋白乙酰化过程的调节 ,在基因表达调控中发挥着重要作用。HAT和 HDAC的异常与肿瘤发生有密切的关系
The acetylation of N-terminal lysine residues in eukaryotic histones is related to the transcriptional activation of genes. A variety of regulatory factors with histone acetylase (HAT) and histone deacetylase (HDAC) activity play an important role in the regulation of gene expression through the regulation of histone acetylation. HAT and HDAC abnormalities are closely related to tumorigenesis