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目的探讨前列地尔联合还原型谷胱甘肽治疗急性肾损伤的临床疗效。方法 60例急性肾损伤患者随机分为实验组及对照组,每组30例。对照组予以还原型谷胱甘肽治疗,实验组予以前列地尔联合还原型谷胱甘肽治疗,实验结束后,对两组患者病情控制时间、住院时间、多尿期时间、少尿期时间、血肌酐恢复时间以及不良反应发生率进行比较分析。结果实验组患者病情控制时间、住院时间、多尿期时间、少尿期时间、血肌酐恢复时间均明显短于对照组,差异具有统计学意义(P<0.05)。实验组不良反应发生率为3.3%,明显低于对照组的26.7%,差异具有统计学意义(χ2=6.405,P<0.05)。结论前列地尔联合还原型谷胱甘肽治疗急性肾损伤疗效显著,安全性较高,不良反应较少,值得临床推广应用。
Objective To investigate the clinical efficacy of alprostadil combined with reduced glutathione in the treatment of acute kidney injury. Methods Sixty patients with acute renal injury were randomly divided into experimental group and control group, 30 cases in each group. The control group was treated with reduced glutathione, the experimental group was treated with alprostadil combined with reduced glutathione, after the experiment, the two groups of patients with disease control time, hospitalization time, polyuria period, oliguria period , Serum creatinine recovery time and the incidence of adverse reactions were compared. Results The patients in the experimental group had significantly shorter disease control time, hospitalization time, polyuria period, oliguria period, and serum creatinine recovery time than those in the control group (P <0.05). The incidence of adverse reactions in the experimental group was 3.3%, which was significantly lower than that in the control group (26.7%), the difference was statistically significant (χ2 = 6.405, P <0.05). Conclusions Alprostadil combined with reduced glutathione for the treatment of acute kidney injury has obvious curative effect, high safety and few adverse reactions, which is worthy of clinical application.