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维生素D受体（ VDR）基因在人体组织中广泛表达，它的4个单核苷酸多态性位点 FokⅠ、BsmⅠ、ApaⅠ和TaqⅠ与多种疾病发生均有关联。该文就近年来国内外所开展的 VDR 基因多态性与支气管哮喘、结核病、1型糖尿病、自身免疫性疾病和肿瘤的相关性进行综述，发现 VDR基因多态性存在较大的种族差异，并可能受饮食、生活习惯、环境因素等的影响。 VDR基因多态性的研究为进一步明确疾病的发病机制提供了理论基础。“,”Vitamin D receptor ( VDR ) gene is widely expressed in human tissues, it has four single nucleotide polymorphisms loci FokⅠ,BsmⅠ,ApaⅠ and TaqⅠ which are associated with many diseases. Here is to make a review of the association between VDR polymorphisms with bronchial asthma,tuberculosis, type 1 diabetes,autoimmune diseases and cancer.It is discovered that,VDR gene polymorphisms have racial differences,and may be affected by diet,lifestyle and other environmental factors.The research on the genetic polymorphisms of VDR has provided theoretical basis to further clarify the pathogenesis .