论文部分内容阅读
借助犬双后肢高速、低速投射物致伤应激模型，对内皮素－１（ＥＴ１）在神经－体液中的表达与释放进行动态观察和定量分析，旨在进一步探索非颅脑致伤中枢神经系统（ＣＮＳ）应变内环境紊乱的某些病理生理基础。结果发现伤后体液、脑组织匀浆ＥＴ１较伤前及对照组显著升高，尤以高速组明显；低速组下丘脑，高速组下丘脑、海马区ＥＴ１－ｍＲＮＡ表达较对照组显著增强。提示虽未直接伤及大脑，但对ＣＮＳ可有不同范围、不同程度的间接损害作用；且不同应激强度，对ＣＮＳ产生不同程度的影响。表明ＣＮＳ在全身应激反应基础上有其自身特殊规律。
With the aid of high speed and low velocity projectile stress model of canine hindlimbs, dynamic observation and quantitative analysis of the expression and release of endothelin-1 (ET1) in neuro-humoral cells aimed to further explore the non-craniocerebral injury central nervous system System (CNS) Some of the pathophysiological basis for strained internal environmental disturbances. The results showed that the level of ET1 mRNA in hypothalamus and hippocampus in hypothalamus and high-speed group was significantly higher than that in control group in low-speed group. Although not directly hurt the brain tips, but there are different degrees of CNS may have indirect effects of damage; and different stress intensity, varying degrees of impact on the CNS. Show that CNS has its own special rules based on systemic stress response.