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目的观察小剂量肝素治疗小儿全身炎症反应综合征(SIRS)的临床价值。方法将符合诊断标准的59例SIRS患儿设为观察组,早期应用小剂量肝素持续静脉滴注,观察临床效果及血小板计数及CRP水平变化。既往未用肝素治疗的56例SIRS患者为对照组,回顾分析临床资料并与观察组比较。结果观察组治疗前后比较,血小板计数明显升高,CRP水平明显下降(P<0.05)。多脏器功能不全(MODS)发生率较对照组显著降低(P<0.05),SIRS持续时间缩短。结论持续小剂量肝素静脉滴注可缩短SIRS持续时间,降低MODS发生率及患儿死亡率。
Objective To observe the clinical value of low-dose heparin in treating systemic inflammatory response syndrome (SIRS) in children. Methods Fifty-nine children with SIRS meeting the diagnostic criteria were enrolled in the observation group. Low-dose heparin infusion was used in the early stage to observe the clinical effect and the changes of platelet count and CRP level. Fifty-six patients with SIRS that had not been treated with heparin were compared with the control group. The clinical data were retrospectively analyzed and compared with the observation group. Results Before and after treatment, the platelet count was significantly increased and CRP level was significantly decreased (P <0.05). The incidence of multiple organ dysfunction (MODS) was significantly lower than that of the control group (P <0.05), and the duration of SIRS was shortened. Conclusion Continuous low-dose heparin intravenous infusion can shorten the duration of SIRS, reduce the incidence of MODS and mortality in children.