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消癃通闭浸出液与犬大脑皮层粗制膜及IBE12 5作用测定其对IBE12 5与犬大脑皮层α1 AR结合的抑制作用 ,结果消癃通闭对IBE12 5犬大脑皮层的结合呈竞争性拮抗作用 ,IC50 为 3 4 0± 6 0 g/L ,Hill系数为 0 70± 0 0 6,佐证本方具有α1 AR拮抗作用。
The inhibitory effect of apoptotic pass-through leachate and crude plasma membrane of canine cerebral cortex and IBE12 5 on the binding of IBE125 to canine cerebral cortex α1 AR was investigated. The results indicated that the elimination of pupation and opening-closing was a competitive antagonism on the binding of canine cerebral cortex IBE125. The IC50 was 3 4 0 ± 60 g/L and the Hill coefficient was 0 70 ± 0 0 6. It was confirmed that this side had α1AR antagonistic effect.