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目的:通过对窒息新生儿胆红素测定,以探讨胆红素抗自由基作用。方法:计100例新生儿分为两组,窒息组及正常对照组,各50例;窒息组中又分为两组,轻度窒息及重度窒息组,各25例,均于生后第3天抽静脉血,测定总胆红素。结果:窒息儿组胆红素浓度较正常儿组低,两组比较有显著差异,P<0.01;重度窒息儿组胆红素浓度较轻度窒息儿组低,两组亦有显著差异,P<0.01。结论:提示新生儿窒息时胆红素作为抗氧化剂自身被消耗,胆红素有抗自由基作用。
Objective: To explore the anti-free radical effect of bilirubin through the determination of bilirubin in neonatal asphyxia. Methods: 100 newborns were divided into two groups, asphyxia group and normal control group, 50 cases in each group. The asphyxia group was divided into two groups, mild asphyxia group and severe asphyxia group, 25 cases in each group. After birth, Days pumping venous blood, total bilirubin. Results: The bilirubin concentration in asphyxia group was lower than that in normal group, there was a significant difference between the two groups (P <0.01). The level of bilirubin in severe asphyxia group was lower than that in mild asphyxia group. There was also significant difference between the two groups <0.01. Conclusion: It suggests that bilirubin itself is consumed as anti-oxidant during neonatal asphyxia, and bilirubin has anti-free radical effect.